What is the genetic structure of rotavirus?
The genome of rotavirus contains 11 double-stranded RNA segments with 18,555 base pairs. Each of these segments is a gene, numbered from 1 to 11 by decreasing size. Every genome segment codes for one protein required for the viral lifecycle, except for genome segment 11 that encodes for two proteins.
Does rotavirus have segmented genome?
The rotavirus (RV) genome comprises 11 segments of double-stranded RNA (dsRNA) and is contained within a non-enveloped, icosahedral particle. During assembly, a highly coordinated selective packaging mechanism ensures that progeny RV virions contain one of each genome segment.
How is the virus genome replicated?
During attachment and penetration, the virus attaches itself to a host cell and injects its genetic material into it. During uncoating, replication, and assembly, the viral DNA or RNA incorporates itself into the host cell’s genetic material and induces it to replicate the viral genome.
Where does the replication of rotavirus occur?
Unique to rotavirus is that replication occurs in the viroplasm, a compartment within the cytoplasm of the cell. If two rotaviruses infect a cell, the replication of both occurs within a single viroplasm.
Which two of the following are effective rotavirus vaccines?
There are two rotavirus vaccines licensed for use in infants in the United States:
- RotaTeq® (RV5), which is given in three doses at 2 months, 4 months, and 6 months of age.
- Rotarix® (RV1), which is given in two doses at 2 months and 4 months of age.
What is transcription in viruses?
Abstract. Genome transcription is a critical stage in the life cycle of a virus, as this is the process by which the viral genetic information is presented to the host cell protein synthesis machinery for the production of the viral proteins needed for genome replication and progeny virion assembly.
